Investigation of inter- and intra-tumoral heterogeneity of glioblastoma using TOF-SIMS
datasetposted on 11.10.2019 by Ksenia Anufrieva
Datasets usually provide raw data for analysis. This raw data often comes in spreadsheet form, but can be any collection of data, on which analysis can be performed.
Here, we for the first time applied TOF-SIMS (Time-of-flight secondary ion mass spectrometry) to study glioma tumors and cells with 800 nm resolution. We also developed a method that allows to simultaneously detect distribution of proteins and metabolites in tumor sections using TOF-SIMS. Our results demonstrate that according to TOF-SIMS data glioma samples can be subdivided into clinically relevant groups and distinguished from the normal brain tissue.