Data for: Pharmacokinetics of two Bis-pyridinium Aldoximes
datasetposted on 22.07.2019, 10:17 by Huba Kalász, Syed Nurulain, Ernest Adeghate, Kornelia Tekes, Gellér Karvaly, Kamil Musilek, Kamil Kuca, Young Sik Jung
Aims: K117 and K127 are bis-pyridinium aldoximes. Both K117 and K127 are developed as potential antidotes in the case of poisoning both acetylcholinesterase and butyrylcholinesterese in terrorist attacks or intoxication with other organophosphorous compounds. Their distribution has been scouted in the body of rats. Main methods: White male Wistar rats were intramuscularly injected. The animals were sacrificed, tissue samples were homogenized, and either K117 or K127 concentrartions were determined using reversed-phase high-performance liquid chromatography. Key findings: Both K117 and K127 were present in all tissues that were analyzed including blood (serum), the brains, cerebrospinal fluid, the eyes, livers, kidneys, lungs and testes. Two novel proper names should be conceptualized in the practice of these antidotes, t1/10 (instead of t1/2) and maximal blood-brain penetration cmaxBBP.(instead of the individual cmax values for blood and also for the brain). Significance: Either K117 or K127 meets the essential requirements for antidotes. Dose dependence and kinetics of their distribution were compared to that of other pyridinium aldoximes.