MH2c: Characterization of major histocompatibility α-helices – an information criterion approach
datasetposted on 06.12.2019 by B. Hischenhuber, F. Frommlet, W. Schreiner, B. Knapp
Datasets usually provide raw data for analysis. This raw data often comes in spreadsheet form, but can be any collection of data, on which analysis can be performed.
Abstract Major histocompatibility proteins share a common overall structure or peptide binding groove. Two binding groove domains, on the same chain for major histocompatibility class I or on two different chains for major histocompatibility class II, contribute to that structure that consists of two α-helices (“wall”) and a sheet of eight anti-parallel beta strands (“floor”). Apart from the peptide presented in the groove, the major histocompatibility α-helices play a central role for the interaction... Title of program: MH2c (MH helix curves) Catalogue Id: AELX_v1_0 Nature of problem Major histocompatibility (MH) proteins share a similar overall structure. However, identical MH alleles which present different peptides differ by subtle conformational alterations. One hypothesis is that such conformational differences could be another level of T cell regulation. By this software package we present a reliable and systematic way to compare different MH structures to each other. Versions of this program held in the CPC repository in Mendeley Data AELX_v1_0; MH2c (MH helix curves); 10.1016/j.cpc.2012.02.008 This program has been imported from the CPC Program Library held at Queen's University Belfast (1969-2018)