Final analysis of data sets from two grants awarded by the Qatar National Research Fund (QNRF).

2019-07-18T12:46:48Z (GMT) by El Rasheid Zakaria
My research as summarized herein, focuses on the effects of different variables like aging, traumatic hemorrhage, ischemia and re-perfusion injures, osmotic and mechanical cellular stressors on the vascular tone control mechanisms, and on the molecular mechanisms of the associated vascular and interstitial tissue remodeling. As independent investigator during the past 7 years, I developed the State of Qatar’s first basic biomedical research that uses animals, together with the oversight committee (IACUC) for the program. This was achieved by two competitive peer reviewed grants summing $1.5 M as awarded by the Qatar National Research Fund. The work in these two grants (summarized in the two technical report documents), was centered to study the pathophysiology of the blood peritoneal barrier at the cellular and interstitial levels during acute and chronic exposures of the peritoneal cavity to sterile glucose-based peritoneal dialysis solution; separately we examined the efficacy and effectiveness in terms of short and long term outcome of direct endothelial-cytosolic energy (ATP) delivery as adjunct to resuscitation from traumatic exsanguination. The final goal from this research was to determine the molecular mechanisms of peritoneal membrane dysfunction/failure and to device methods to improve peritoneal dialysis technique survival and longevity; and to improve resuscitation outcome of progressive hemorrhagic shock.